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Application of Neutrophil-lymphocyte Ratio in the Diagnosis of Influenza in Preschool Children

Received: 13 November 2019     Accepted: 27 November 2019     Published: 6 December 2019
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Abstract

Objective: To analyze the prevalence of influenza A/B in preschool children and neutrophils to lymphocytes ratio (NLR) of influenza A/B positive patients and patients with influenza-like illness, in order to provide more ideas and basis for the prevention, diagnosis and treatment of influenza-like illness. Methods: Children who were not more than 6 years old, and screened for antigen of influenza viruses in the Second Affiliated Hospital of Xi'an Jiaotong University, were enrolled in this study from November 2017 to February 2018. The venous blood or finger tip blood of the participants were collected for blood routine test. SPSS 19.0 software was used to analyze data. Results: Totally 99 (26.19%) cases with positive influenza A were observed in 378 children with influenza-like illness, 44 (11.64%) cases with positive influenza B, and the 225 cases were not infected. There was significant difference on the value of NLR between patients with influenza A infection and children without infection (P<0.05). When NLR was 0.42, the sensitivity for the prognosis was 86.1%, the specificity was 93.2%, and the area under curve (AUC) was 0.594. Conclusion: NLR has certain clinical value for the diagnosis of Influenza influenza, and can be helpful to diagnose influenza A virus infection by influenza virus antigen screening.

Published in American Journal of Health Research (Volume 7, Issue 6)
DOI 10.11648/j.ajhr.20190706.11
Page(s) 100-103
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Influenza A, Influenza B, Influenza-like Illness, Blood Routine Test, Neutrophils to Lymphocytes Ratio

References
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[3] He hui, liu jieduo, zhou yingchun, et al. ROC curve evaluation of AFU and AFF in the diagnosis of primary liver cancer. International journal of laboratory medicine, 2006, 27 (2E18).
[4] Luo yi, li jiqiang, zheng danwen, et al. Etiology investigation and clinical characteristics of acute upper respiratory tract infection virus. Chinese journal of traditional Chinese medicine, 2010, 8 (17): 178-181.
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[6] Chen jian, li yan-ting, wang ye, et al. Comparison between colloidal gold method and virus isolation and identification in the diagnosis of influenza. Shanghai journal of preventive medicine, 2008, 20 (12): 573-574.
[7] zhou ying, yu ronghuan, yu ping. Analysis of influenza surveillance in a sentinel hospital in Shanghai from 2007 to 2009]. Shanghai journal of preventiv medicine, 2010, 22 (6): 293-296.
[8] le yanhong, huang fengguang, gao shuping. Analysis of influenza and surveillance results in heyuan city from 2014 to 2016, Chinese tropical medicine, 2018, 18 (1): 80-83.
[9] wang peng, Yang xiaobing, kong deguang, et al. Analysis of influenza surveillance results in wuhan from 2012 to 2017, modern preventive medicine, 2018, 44 (1): 141-144.
[10] letomik. A study on the role of granulocytes carcinoma­bearing hosts-G/L ratio as a new host indicator. Nippon Gan Chiryo Gakkai Shi, 1990, 25 (25): 662-671.
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  • APA Style

    Yuan Xiaohong, Li Peng, Li Yuwei. (2019). Application of Neutrophil-lymphocyte Ratio in the Diagnosis of Influenza in Preschool Children. American Journal of Health Research, 7(6), 100-103. https://doi.org/10.11648/j.ajhr.20190706.11

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    ACS Style

    Yuan Xiaohong; Li Peng; Li Yuwei. Application of Neutrophil-lymphocyte Ratio in the Diagnosis of Influenza in Preschool Children. Am. J. Health Res. 2019, 7(6), 100-103. doi: 10.11648/j.ajhr.20190706.11

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    AMA Style

    Yuan Xiaohong, Li Peng, Li Yuwei. Application of Neutrophil-lymphocyte Ratio in the Diagnosis of Influenza in Preschool Children. Am J Health Res. 2019;7(6):100-103. doi: 10.11648/j.ajhr.20190706.11

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  • @article{10.11648/j.ajhr.20190706.11,
      author = {Yuan Xiaohong and Li Peng and Li Yuwei},
      title = {Application of Neutrophil-lymphocyte Ratio in the Diagnosis of Influenza in Preschool Children},
      journal = {American Journal of Health Research},
      volume = {7},
      number = {6},
      pages = {100-103},
      doi = {10.11648/j.ajhr.20190706.11},
      url = {https://doi.org/10.11648/j.ajhr.20190706.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20190706.11},
      abstract = {Objective: To analyze the prevalence of influenza A/B in preschool children and neutrophils to lymphocytes ratio (NLR) of influenza A/B positive patients and patients with influenza-like illness, in order to provide more ideas and basis for the prevention, diagnosis and treatment of influenza-like illness. Methods: Children who were not more than 6 years old, and screened for antigen of influenza viruses in the Second Affiliated Hospital of Xi'an Jiaotong University, were enrolled in this study from November 2017 to February 2018. The venous blood or finger tip blood of the participants were collected for blood routine test. SPSS 19.0 software was used to analyze data. Results: Totally 99 (26.19%) cases with positive influenza A were observed in 378 children with influenza-like illness, 44 (11.64%) cases with positive influenza B, and the 225 cases were not infected. There was significant difference on the value of NLR between patients with influenza A infection and children without infection (P<0.05). When NLR was 0.42, the sensitivity for the prognosis was 86.1%, the specificity was 93.2%, and the area under curve (AUC) was 0.594. Conclusion: NLR has certain clinical value for the diagnosis of Influenza influenza, and can be helpful to diagnose influenza A virus infection by influenza virus antigen screening.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Application of Neutrophil-lymphocyte Ratio in the Diagnosis of Influenza in Preschool Children
    AU  - Yuan Xiaohong
    AU  - Li Peng
    AU  - Li Yuwei
    Y1  - 2019/12/06
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ajhr.20190706.11
    DO  - 10.11648/j.ajhr.20190706.11
    T2  - American Journal of Health Research
    JF  - American Journal of Health Research
    JO  - American Journal of Health Research
    SP  - 100
    EP  - 103
    PB  - Science Publishing Group
    SN  - 2330-8796
    UR  - https://doi.org/10.11648/j.ajhr.20190706.11
    AB  - Objective: To analyze the prevalence of influenza A/B in preschool children and neutrophils to lymphocytes ratio (NLR) of influenza A/B positive patients and patients with influenza-like illness, in order to provide more ideas and basis for the prevention, diagnosis and treatment of influenza-like illness. Methods: Children who were not more than 6 years old, and screened for antigen of influenza viruses in the Second Affiliated Hospital of Xi'an Jiaotong University, were enrolled in this study from November 2017 to February 2018. The venous blood or finger tip blood of the participants were collected for blood routine test. SPSS 19.0 software was used to analyze data. Results: Totally 99 (26.19%) cases with positive influenza A were observed in 378 children with influenza-like illness, 44 (11.64%) cases with positive influenza B, and the 225 cases were not infected. There was significant difference on the value of NLR between patients with influenza A infection and children without infection (P<0.05). When NLR was 0.42, the sensitivity for the prognosis was 86.1%, the specificity was 93.2%, and the area under curve (AUC) was 0.594. Conclusion: NLR has certain clinical value for the diagnosis of Influenza influenza, and can be helpful to diagnose influenza A virus infection by influenza virus antigen screening.
    VL  - 7
    IS  - 6
    ER  - 

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Author Information
  • Department of Clinical Laboratory, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

  • Department of Clinical Laboratory, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

  • Department of Genetics, Northwest Hospital for Women and Children, Xi'an, China

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