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Serum Mannose Binding Lectin Levels in Early Onset Neonatal Sepsis

Received: 9 April 2015     Accepted: 14 April 2015     Published: 24 April 2015
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Abstract

Introduction: Early Onset Neonatal Sepsis (EONS) is still the most cause of neonatal morbidity and mortality. The diagnosis is difficult to establish because of nonspecific clinical features and laboratory findings. Mannose binding lectin (MBL) is one of the acute phase proteins that can show progressing infection process. Objective: To determine the serum MBL levels of neonates with EONS and not EONS. Methods: This study was conducted as a cross sectional study from September to November 2014. The population included 92 neonates baby whose mother has risk factors of sepsis and admitted to Dr. Wahidin Sudirohusodo Hospital and joined hospital. The subjects were divided into two groups, EONS and Not EONS group based on clinical features and laboratory findings. The MBL serum level was measured on each group. Results: Statistical analyses showed median value of serum MBL of EONS group (0.88 μg/mL) was significant lower compare with Not EONS group (0.93 μg/mL), with p= 0.00 (p<0.05). The cutoff point of ≤0.93 µg/mL is the best levels to distinguish between EONS and Not EONS (p=0.01, sensitivity 76%, specificity 56%, positive predictive value 60%, negative predictive value 67%, COR 3.182, 95%CI 1.306-7.752). Conclusion: MBL serum levels on EONS group were lower than Not EONS group.

Published in American Journal of Health Research (Volume 3, Issue 3)
DOI 10.11648/j.ajhr.20150303.14
Page(s) 135-139
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Mannose Binding Lectin, Early Onset Sepsis, Neonates

References
[1] Alamsyah, Effek. Epidemiological analysis of neonatal maternal health efforts in Indonesia in achieving the target of millenium development goals (mdgs) 2015. Buletin Perinasia. 2010; (1).
[2] WHO. Neonatal sepsis - A major killer to be tackled in communities. www.who.int/maternal_child_adolescent. 2010.
[3] Karanda, I Made. Incidence and Factors Associated With Mortality Of Neonatal Sepsis. Pediatrica Indonesiana. 2011; Vol.51.
[4] Gomella, T.L., Cunningham, M.D., Eyal, F.G., Zenk, K.E. Infectious Diseases. In Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs. 5th ed. McGraw-Hill Companies. 2004; h.434-81.
[5] Zaghouani H, Hoeman CM. Neonatal immunity : Faulty T Helper and Shortcoming Of Dendritic Cells. Trends Immunol; 2009; 30: 585-591.
[6] Thiel S. Complement Activating Soluble Pattern Recognotion Molecules With Collagen-Like Regions, Mannan-Binding Lectin, Ficolins And Associated Proteins. Mol Immunol. 2007; 44: 3875-3888.
[7] Özkan, H., Köksal, N., Çetinkaya, M, Kιlιç Ş., Çelebi S, Oral, B., et al. Serum mannose-binding lectin (MBL) gene polymorphism and low MBL levels are associated with neonatal sepsis and pneumonia. Journal of Perinatology. 2012; 32, 210-217.
[8] Benedetti, F.D., Auritia, C., Prenciped, G., Inglesec, R., Azzarie, C., Ronchettia, M.P., Tozzib, A., Segantia, R., and Orzalesia, M. Role of Mannose-Binding Lectin in Nosocomial Sepsis in Critically Ill Neonates (Online). Human Immunology. Itali. 2010; Vol 71: 1084-8.
[9] Schlapbach L.J., Mattmann M., Thiel S., Boillat C., Otth M., Nelle M., et al. Differential Role of the Lectin Pathway of Complement Activation in Susceptibility to Neonatal Sepsis. 2010. 1058-4838/2010/5102-0006.
[10] Hibberd, Martin L., Summerfield, John A. Levin, Michael. Variation in Mannose Binding Lectin (MBL) Gene and Susceptibility to sepsis. Departemen of Paediatrics and Medicine, Imperial College Faculty of Medicine. London. Springe. 2001; 4 (3): 201-207.
[11] Barbara J. Stoll, Nellie Hansen, Avroy A. Fanaroff, Linda L. Wright, Waldemar A. Carlo,Richard A. Ehrenkranz, et.al.. Changes in Pathogens Causing Early-Onset Sepsis in Very-Low-Birth-Weight Infants. The New England Journal of Medicines. 2002; 347:240-247.
[12] Frakking, F.N.J., Brouwer, N., Eijkelenburg, N.K.A. van, Merkus, M.P., Kuijpers, T.W., Offringa, M., and Dolman, K.M. Low Mannose-binding Lectin (MBL) Levels in Neonates with Pneumonia and Sepsis. British Society for Immunology, Clinical and Experimental Immunology. 2007; 150: 255-62.
[13] Health Ministry of Indonesia. Management of Sepsis Neonatorum. www.buk.depkes.go.id. 2007.
[14] Mohamed, W. A. Wahab and Saeed, M. A. Mannose-Binding Lectin Serum Levels in Neonatal Sepsis and Septic Shock. Journal of Maternal-Fetal and Neonatal Medicine. 2012; 25 (4): 411–414.
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  • APA Style

    Andi Risko Amalia, Ema Alasiry, Dasril Daud. (2015). Serum Mannose Binding Lectin Levels in Early Onset Neonatal Sepsis. American Journal of Health Research, 3(3), 135-139. https://doi.org/10.11648/j.ajhr.20150303.14

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    ACS Style

    Andi Risko Amalia; Ema Alasiry; Dasril Daud. Serum Mannose Binding Lectin Levels in Early Onset Neonatal Sepsis. Am. J. Health Res. 2015, 3(3), 135-139. doi: 10.11648/j.ajhr.20150303.14

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    AMA Style

    Andi Risko Amalia, Ema Alasiry, Dasril Daud. Serum Mannose Binding Lectin Levels in Early Onset Neonatal Sepsis. Am J Health Res. 2015;3(3):135-139. doi: 10.11648/j.ajhr.20150303.14

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  • @article{10.11648/j.ajhr.20150303.14,
      author = {Andi Risko Amalia and Ema Alasiry and Dasril Daud},
      title = {Serum Mannose Binding Lectin Levels in Early Onset Neonatal Sepsis},
      journal = {American Journal of Health Research},
      volume = {3},
      number = {3},
      pages = {135-139},
      doi = {10.11648/j.ajhr.20150303.14},
      url = {https://doi.org/10.11648/j.ajhr.20150303.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20150303.14},
      abstract = {Introduction: Early Onset Neonatal Sepsis (EONS) is still the most cause of neonatal morbidity and mortality. The diagnosis is difficult to establish because of nonspecific clinical features and laboratory findings. Mannose binding lectin (MBL) is one of the acute phase proteins that can show progressing infection process. Objective: To determine the serum MBL levels of neonates with EONS and not EONS. Methods: This study was conducted as a cross sectional study from September to November 2014. The population included 92 neonates baby whose mother has risk factors of sepsis and admitted to Dr. Wahidin Sudirohusodo Hospital and joined hospital. The subjects were divided into two groups, EONS and Not EONS group based on clinical features and laboratory findings. The MBL serum level was measured on each group. Results: Statistical analyses showed median value of serum MBL of EONS group (0.88 μg/mL) was significant lower compare with Not EONS group (0.93 μg/mL), with p= 0.00 (p<0.05). The cutoff point of ≤0.93 µg/mL is the best levels to distinguish between EONS and Not EONS (p=0.01, sensitivity 76%, specificity 56%, positive predictive value 60%, negative predictive value 67%, COR 3.182, 95%CI 1.306-7.752). Conclusion: MBL serum levels on EONS group were lower than Not EONS group.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Serum Mannose Binding Lectin Levels in Early Onset Neonatal Sepsis
    AU  - Andi Risko Amalia
    AU  - Ema Alasiry
    AU  - Dasril Daud
    Y1  - 2015/04/24
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajhr.20150303.14
    DO  - 10.11648/j.ajhr.20150303.14
    T2  - American Journal of Health Research
    JF  - American Journal of Health Research
    JO  - American Journal of Health Research
    SP  - 135
    EP  - 139
    PB  - Science Publishing Group
    SN  - 2330-8796
    UR  - https://doi.org/10.11648/j.ajhr.20150303.14
    AB  - Introduction: Early Onset Neonatal Sepsis (EONS) is still the most cause of neonatal morbidity and mortality. The diagnosis is difficult to establish because of nonspecific clinical features and laboratory findings. Mannose binding lectin (MBL) is one of the acute phase proteins that can show progressing infection process. Objective: To determine the serum MBL levels of neonates with EONS and not EONS. Methods: This study was conducted as a cross sectional study from September to November 2014. The population included 92 neonates baby whose mother has risk factors of sepsis and admitted to Dr. Wahidin Sudirohusodo Hospital and joined hospital. The subjects were divided into two groups, EONS and Not EONS group based on clinical features and laboratory findings. The MBL serum level was measured on each group. Results: Statistical analyses showed median value of serum MBL of EONS group (0.88 μg/mL) was significant lower compare with Not EONS group (0.93 μg/mL), with p= 0.00 (p<0.05). The cutoff point of ≤0.93 µg/mL is the best levels to distinguish between EONS and Not EONS (p=0.01, sensitivity 76%, specificity 56%, positive predictive value 60%, negative predictive value 67%, COR 3.182, 95%CI 1.306-7.752). Conclusion: MBL serum levels on EONS group were lower than Not EONS group.
    VL  - 3
    IS  - 3
    ER  - 

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Author Information
  • Department of Pediatrics, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia

  • Department of Pediatrics, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia

  • Department of Pediatrics, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia

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